Canagliflozin blocks post-meal glucose spikes, extends lifespan in mice, and shows preferential effects in males, suggesting a similar mechanism to acarbose.

“because of a drug you haven't mentioned yet canagliflozin which was just published a few weeks ago canagliflozin which is also used for diabetes in people also blocks peak glucose in mice and in people and it also extends life span and it also works preferentially in males so it's a reasonable guess that both acarbose and canagliflozin are working by eliminating the huge peak of glucose you get after you eat a meal with a lot of starch in it”