The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
most of the toxic effects of alcohol are mediated by the alcohol metabolism that produces acetaldehyde which is going to result in problems with lipid peroxidation like can be seen in this paper alcohol ingestion liver glutathione lipoperoxidation etc
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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well what the problem is ethanol in the brain also because it's polar and it dissolves lipids it also creates acetaldehyde so that's the first step in terms of metabolism of ethanol which then can cause that mired reaction because you've made an aldehyde which then generates reactive oxygen species so you can kill neurons not necessarily from excitation but from the biochemistry of the molecule
acety alahh toxicity is another mechanism I want to talk about when you drink alcohol your body metabolizes it into acetyl alahh a substance that is toxic to brain cells this compound can damage DNA and proteins within brain cells leading to Cellular dysfunction and cell death