Binge drinking, defined as 3-4 drinks for women and 4-5 drinks for men, can cause significant LPS release from the intestines.

“binge drinking is something that also has been identified to cause massive lps release from the intestines um probably a lot of people that already have underlying gut issues are more familiar with this because they've probably noticed when they drink alcohol they might start to have gut issues uh and and and so binge drinking this is this is for women about three to four drinks and for men like four to five so it's a lot”

“you don't have to be a chronic heavy drinker to experience these effects a single binge drinking occasion consuming four or more drinks in a single occasion elevates LPS levels in the bloodstream for up to 3 hours”