Peter Attia· MD
and if you are going to have a drink here are some principles for how you might minimize the damage right in terms of the number you might have how long you might have it before bed that kind of thing
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and if you are going to have a drink here are some principles for how you might minimize the damage right in terms of the number you might have how long you might have it before bed that kind of thing
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how do you feel about apoe4 carriers and alcohol consumption like our view in the practice is that they are indeed more susceptible um to the deleterious effects of alcohol um and also I would say they're just more susceptible in general to the deleterious effects of poor sleep which is one of the ways that I think alcohol is disproportionately hurting the brain um you know I think poor sleep is is causally driving Alzheimer's risk and cardiovascular disease risk
increasing alcohol consumption in midlife increases dementia risk only in adults carrying one or more copies of the apoe4 AIL at least when alcohol consumption stays below the threshold discussed earlier
ape4 carriers don't appear to experience the protective effect of light to moderate alcohol consumption that non-carriers have whereas most other epidemiological studies show that light to moderate drinking is associated with a lower dementia risk in people without the ap4 alil
for adults with one or more copies of the apoe4 AIL any alcohol was associated with a greater risk of cognitive decline with 90% greater risk for two or less drinks per day a 170% increased risk for two to five drinks per day and a 730% increase risk for five or more drinks per day
carriers of the apo4 AIL who consumed alcohol less than once a month still had 2.3 times greater risk of dementia than carriers who never drank and carriers who drank several times per month had 3.6 times greater risk of Alzheimer's disease
if you're a carrier of one or two of the apil we4 alals zero drinks per day is associated with the lowest risk for neurocognitive diseases
Some evidence suggests that the risk of dementia increases along with increasing alcohol consumption in people with one or more copies of the apo4 AIL but not in people without the APO 4il
light to moderate alcohol consumption might reduce the risk of Dementia in individuals without an apoe4 alil which is a known genetic risk factor for Alzheimer's disease this protective effect could be due to alcohol's influence on cardiovascular health possibly improving blood flow to the brain and reducing inflammation which are crucial factors in maintaining cognitive function