Lifestyle interventions are effective for Alzheimer's disease prevention in individuals with the ApoE3/4 genotype.

“the person that walks in with an e3 e4 I am actually more optimistic when they come in and less freaked out about the four because at least I know what I'm up against okay if that person's you have so many three fours in your cohort now easy easy I know lifestyle interventions work I am confident that when I do XYZ ABC the 27 things that I'll tell them to do based on precision medicine based on their metabolic risk factors their cholesterol their individual risks I can predict that they will have a response of this and this is satisfying to me”