Individuals with the APOE4 genotype are more negatively impacted by sedentary lifestyles regarding Alzheimer's pathology and should prioritize exercise.

“physical exercise is i believe likely preferentially effective in people with the e4 variant or more brain imaging studies show that e4 carriers exacerbates the effect of having a sedentary lifestyle in alzheimer's pathology”

“so someone with e4 really really really better exercise and it's like no joke it's got to be really important and and the intensity of the exercise is key”

“and the intensity of the exercise is key”

“So exercise has been shown to people with ApoE4 allele are much, much less likely to get Alzheimer's if they exercise, the more intensely the better.”