Paul Saladino· MD
there's no therapy targeting amyloid has been shown to be beneficial and the amyloid plaque burn doesn't correlate with cognitive outcomes or trajectory of Alzheimer's disease
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there's no therapy targeting amyloid has been shown to be beneficial and the amyloid plaque burn doesn't correlate with cognitive outcomes or trajectory of Alzheimer's disease
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the amount of amyloid that you've accumulated doesn't correlate with outcomes
I think you know I have to reach deep into the depths of my memory and if people have tried to do that kind of um correlation it's you know the r is somewhere around 0.1 or something — so you know which just means for people it's virtually uncorrelated