Inflammation may play a significant role in Alzheimer's disease and atherosclerosis, as indicated by cases where low inflammation correlated with absence of disease.

“i have become probably more convinced at the importance of inflammation certainly in alzheimer's disease and certainly in atherosclerosis because i've seen enough people who [Music] either develop these conditions without otherwise clear reasons for it and vice versa right people who do have other risk factors and don't go on to develop um but have you know at least have a demonstrably low measured amount of of inflammation again the question becomes do you target is there a direct target of inflammation or do you simply reduce inflammation by targeting these other mechanisms which we'll we'll get to”