Amyloid accumulation may be an epiphenomenon or a response to neuronal stress rather than a core pathological process.

“you get to a point and they've shown this very clearly in animal models where if you can force amyloid plaques to accumulate in large numbers where they do start to become damaging in their own right but up to that point um it may be more of an Epi phenomenon or a you know a response to a neuronal stress rather than this core sort of underlying um pathological process”