Amyloid plaques and Tau neurofibrillary tangles are pathological protein aggregates found in Alzheimer's disease and other neurodegenerative conditions.

“these like pathological accretion of proteins like people have heard of amyloid plaques um Tau neurofibrillary Tangles so the two proteins that misfault like misfold or aggregate within the brain that can either be outside of cells as you generally see with amyloid or inside of cells you generally see with Tau”