The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
like in those instances like there's no debate about it like ketones are the necessary and preferred fuel source we're calling type 3 diabetes resistant like insulin resistance of the brain Alzheimer's Parkinson's traumatic brain injury your brain has an inability to utilize that that fuel source
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It does seem to suggest that alternative sources of fuel for the brain such as ketone bodies may play a role in slowing down disease severity...but we need more evidence before this conclusion can be made.
But I think in the context of, like, aging and a context of traumatic brain injury or pathology, I think the brain will really prefer to use ketones because...or in the context of some kind of stress hypoglycemia or something like that, I think the brain will also prefer to use ketones.
So, this is something that I'm excited about. And there's a neurologist that was under me at NIA that he's actually finishing up a study of intermittent fasting and people at risk for cognitive impairment. And he may be one of the places where these ketone ester studies are done.
Ketones as an alternative energy substrate makes sense. In the context of, you know, athletes, you're kind of doing that with chronic ketosis.