A ketogenic diet high in saturated fats and low in carbohydrates improved a heterozygous APOE4 male with type 2 diabetes's Montreal Cognitive Assessment score, reversed his type 2 diabetes, improved markers of metabolic syndrome, and led to weight loss.

“the results of the case study suggests that a clinically prescribed ketogenic diet strong potential to restore systemic insulin sensitivity metabolic sensitivity metabolic flexibility in a diabetic even an apoe4 heterozygous carrier”

“but everything got better in this individual his metabolic sensitivity got better his dementia improved based on his mocha rating and he lost weight so at least in this case study we can substantiate or begin to look with more favorability toward the notion that apoe4 does not mean dementia necessarily”

“Time-restricted eating, a ketogenic diet, and exercise improved cognitive function and markers of metabolism including triglycerides, VLDL, and HbA1c in a 71-year-old woman with ApoE4 that has mild Alzheimer's disease and metabolic syndrome (case study).”