Autosomal dominant mutations in PSEN1, PSEN2, or APP genes can cause early-onset Alzheimer's disease.

“what's these gene that is almost a gerund priests in Dillon one priests Anil into an amyloid precursor protein gene mutation these are three genes that cause true early onset Alzheimer's meaning you have the gene and you get the disease in your 40s or 50s this is one of the only deterministic genes for AD correct it's exceedingly rare less than 1%”

“so there's the typical early onset genes there's really only three uh presynalin one presinalin2 and amyloid precursor protein gene mutation”

“it may be that pscn1 mutation psen2 app mutations which are all these essentially essentially autosomal dominant deterministic mutations that result in people getting this disease and getting it very early I mean this is not uncommon for someone to be stricken in their night in their 40s and certainly be dead before they're 60.”