Multiple insults and metabolic changes can lead the brain to produce amyloid, and inflammation on top of amyloid production is associated with a worse degenerative process.

“So there are multiple different insults and metabolic changes that lead the brain to produce this stuff. And so I think there's been confusion because it's clear that when you produce it you're at this increased risk for having a degenerative process, but as you indicated, there are many people that produce it and they successfully are protecting themselves, they don't actually have the downsizing. What's often been stated is those who then have inflammation on top of that seem to be the ones that do worse, and that's a very general idea, but really it is a set of things.”