Peter Attia· MD
ApoE is a gene it exists mostly in three types though I'd been told there were actually a couple of others but for the large part there's an AoE two and apoE three and an ape oe4
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
ApoE is a gene it exists mostly in three types though I'd been told there were actually a couple of others but for the large part there's an AoE two and apoE three and an ape oe4
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there are three alleles for the APO E4 genes so just to be clear APO e is a gene it codes for a protein unsurprisingly called apoe but we have three different versions of that Gene circulating in our gene pool and to be clear none of these are called mutations right these are all three wild type alleles so one is E2 one is E3 and one is E4
E3 is the most common and E4 is the next most common and E2 is is quite rare
the general prevalence of these is I think 50 to 55 percent are three three about 25 are three four um two four I think is the next most common not that common probably about five to ten percent and uh two two is the rarest four fours in the is the second rarest
so the apoe gene has three isoforms the two three the four isopor all are relatively common I mean the three being the most common then the four the two is not that common but but all would be considered quote unquote normal variants one obviously comes with a much higher risk of neurodegenerative disease