APOE4 may be protective of cognition in the absence of insulin resistance and hyperglycemia.

“if insulin resistance is the major risk factor for for some of the negative effects of apple you for on cognitions at hyperglycemia and you know problems with insulin signaling because insulin is a growth factor is it potentially important to like keep your keep you sells happy to an extent you know if you don't have diabetes and you have a pony for it may even be protective at least in this you know if you sort of like go back to something that's closer to our you know more recent origins”