Alzheimer's disease can develop through multiple pathways, including microvascular disease, diabetes, and mitochondrial dysfunction.

“like yeah you 12 or CA yeah I mean I talk because I'm sort of a simpleton on this topic I generally refer to it as three or four different paths to the same place where you have the same final common pathway everybody's accumulating amyloid beta and tau but you can get there through micro vascular disease which then becomes basically eye disease of hypoxia you can get there through diabetes which then becomes an energetic problem you can get there as you describe through a separate sort of mitochondrial dysfunction”