A minimally processed diet, adequate sleep, exercise, not smoking, and avoiding systemic insulin resistance or diabetes can mitigate APOE4 genotype risks.

“you could argue that you know maybe we don't know yet which factors in the environment are the most uh important but you could imagine a scenario where somebody eats a minimally processed diet sleeps exercises you know doesn't smoke uh is apoe4 then you know avoids so avoids systemic insulin resistance or types of diabetes or pre-diabetes in that setting is Apple E4 a risk factor I would argue probably not or it would dramatically decrease uh the likelihood of their of there being an issue”