Rhonda Patrick· PhD
So, any sort of pathogens, anything that's giving you inflammation, whether you have it because you have a leaky gut or because you have P. gingivalis in your brain, or because you have Borrelia of Lyme disease, or you've been exposed to specific fungi, things like that, all of these things can engender that response. And in fact, we think more and more of amyloid as being like napalm. You got the bad guys coming across the border, so you're now going to put down stuff that kills the bad guys, the napalm but in so doing you're now going to reduce your arable soil. You're now living in a smaller country, and that's exactly what's going on in the brain, you are downsizing the overall network. So, that's what we call type 1 or inflammatory or hot Alzheimer's. And I should mention, it turns out ayurvedic physicians from thousands of years ago who recognized dementia that was related to something that was hot, that was abnormal and ultimately inflammatory, as well as that was related to dryness, which is what we call type 2, where you have decreased trophic support. It can be nerve growth factor, brain-derived neurotrophic factor, estradiol, testosterone, pregnenolone, progesterone, thyroid, vitamin D, all of these things are critical to support of synaptogenesis.