Peter Attia· MD
it turns out neurodegenerative diseases there's an accumulation of toxic protein aggregates and if you enhance autophagy in preclinical models that is has benefit
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it turns out neurodegenerative diseases there's an accumulation of toxic protein aggregates and if you enhance autophagy in preclinical models that is has benefit
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So one strategy to treat neurodegeneration, at least theoretically, is to increase autophagic turnover. And so, one technique is actually then to stimulate general autophagy by increasing the demand, by starvation, or by biochemical trickster that substitute for starvation, and to reduce the protein aggregates that are the cause of the disease.