Paul Saladino· MD
I really think actually one of the primary villains in you know multiple forms of dementia including Alzheimer's disease is vascular you know it's vascular dysfunction
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I really think actually one of the primary villains in you know multiple forms of dementia including Alzheimer's disease is vascular you know it's vascular dysfunction
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so in my opinion that that sort of puts of course the the vascular function and blood brain barrier Integrity Upstream of amyloid in a way because you'll lead you know having that dysfunction first will then lead to more you know amyloid accumulation you know if you're not able to clear it out right
that is something that is happening with normal aging and we know now that this is something that is accelerated in people that go towards dementia and this is true in Alzheimer's disease which is the major cause I mean the the main dementia form resourceful smooth vessel diseases will talk about this versus vascular damage of his different kind but the the commonality about all these Dimensions is they have a vascular component that is quite early in the disease