Amyloid buildup in the brain might indicate a plumbing problem rather than being causative of Alzheimer's.

“perhaps what if it's you know it's building up not because amyloid is inherently bad but because there's some kind of plumbing problem for example you know similar to in heart disease you know you that you could say that there's a plumbing problem in the liver and that's what leads to you know LDL basically you're lingering in circulation too long and then becoming sticky and tricky and causing you know atherogenic plaques”