The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
I think the type 2 diabetes is disrupting the blood-brain barrier through a variety of mechanisms including you know the the advanced glycation end products and the vascular I mean the vasculature disruption in type 2 diabetes is well known
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this what you said about the microvasculature again what I think a lot of people don't realize is how destructive type 2 diabetes is to the kidneys
I think these two other things matter right this what you said about the microvasculature again what I think a lot of people don't realize is how destructive type 2 diabetes is to the kidneys um right because those tiny tiny blood vessels right people are familiar with amputations and things that occur in digits because of that impotence right all of these things where blood vessel is essential in small blood vessels and so there's that which feeds into the vascular path that you've discussed but it's this also this disruption of glucose transport directly across that transporter so I think it's actually a very compelling thesis for how type 2 diabetes could be acting via those two prongs um to to ultimately result in high hypomatabolism
it isn't just an insulin resistance problem but I think these two other things matter right this what you said about the microvasculature um again what what I think a lot of people don't realize is how destructive type 2 diabetes is to the kidneys um right because those tiny tiny blood vessels right people are familiar with amputations and things that occur in digits because of that impotence right all of these things where blood vessel is essential in small blood vessels and so there's that which feeds into the vascular path that you've discussed but it's this also this disruption of gluc glucose transport directly across that transporter so um I think it's actually a very compelling uh thesis for how type 2 diabetes could be acting via those two prongs um to to ultimately result in hypometabolism
The critical link between these genetic and lifestyle factors lies in their shared impact on vascular health, particularly the deterioration of the blood-brain barrier.