Amyloid plaques and Tau neurofibrillary tangles are pathological protein aggregates found in neurodegenerative conditions, including Alzheimer's disease.

“sure so so because of the you know the original way that we understood Alzheimer's disease and and the way that Neuroscience really started was with pathology neuropathology right so you take a section of brain you put it under a microscope and you take a look at it and what we saw in classical Alzheimer's and what you do see in multiple different neurogenitive conditions including age-related dementias is these like pathological accretion of proteins like people have heard of amyloid plaques um Tau neurofibrillary Tangles”