The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
you could also have an apoe4 backslash could be a vascular component here vascular or leakage component and there's a group at usc where i work that has shown that you know there is leakage in the blood-brain barrier allowing toxins to get into the brain and shrink cells
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Vascular leaks are detectable at earliest stages of APOE4 Alzheimer's, but aren't targeted by amyloid therapies!
Importantly, one of the ways it raises this risk is by promoting the early breakdown of the blood-brain barrier.