Non-protein amino acids can accumulate in long-lived proteins in post-mitotic cells like neurons, potentially leading to protein aggregates seen in neurodegenerative conditions.

“these non-protein amino acids can accumulate in proteins that are that are around for a long time that are especially in the neurologic system because these are post mitotic cells the neurons and the retinal pigmented epithelial cells are post-mitotic meaning they stop dividing and they just accumulate proteins right so this type of protein misfolding in those cells could lead to protein aggregates and that's exactly what we see in there is generative conditions parkinson's alzheimer's als et cetera”