Periodontal disease is a promising endpoint for clinical trials in aging due to its quantitative markers and non-invasive assessment.

“my one of my favorites at this at this moment is um periodontal disease and that's because you know my lab has published that in that aged mice get periodontal disease that um uh eight weeks of treatment with rapamycin reverses the clinically defining features of periodontal disease in mice we know that something like two-thirds of older adults have periodontal disease or will get it and those who have periodontal disease are at higher risk for dementia cardiovascular disease diabetes so it's connected in some way to other age-related diseases”