Fibrinogen deposition in the brain indicates blood-brain barrier breakdown in individuals with Alzheimer's disease, small vessel disease, or cognitive impairment.

“we see that um in if you compare a control brain someone cognitively normal though no issues whatsoever and another service brain or a small vessel disease brain you start seeing what we call this um extravascular deposition of fibrinogen is one of the it's one protein that is supposedly in the blood it shouldn't be in the brain at all but we start seeing this extravascular deposition of fibrinogen which means that to cross it has you have to have some degree of breakdown of the of the barrier”