Multiple hits, including leaky blood-brain barrier, predisposition to inflammation, and neuronal energy starvation, can synergistically increase the risk of accelerated disease pathways.

“those hits are synergistic and in the wrong direction right so if you have leaky blood-brain barrier and you're more predisposed to inflammation which again as you pointed out was very helpful 300 000 years ago when we were fraught with parasites you now have two hits within the same hit which is you're more likely to get toxins across the blood-brain barrier which is bad in and of itself and then secondly you're more likely to have an over-reactive immune response to it and if you couple that with say a third hit of neuronal energy starvation these things begin to circle”