A healthy lifestyle may negate the dementia risk associated with the ApoE4 genotype.

“you could argue that you know maybe we don't know yet which factors in the environment are the most important but you could imagine a scenario where somebody eats a minimally processed diet sleeps exercises you know doesn't smoke uh is apoe4 then you know avoids so avoids systemic insulin resistance or types of diabetes or pre-diabetes in that setting is Apple E4 a risk factor I would argue probably not or it would dramatically decrease the likelihood of their of there being an issue”