Amyloid beta may accumulate inside neurons within failing lysosomes, leading to neuronal death and subsequent plaque formation.

“what they showed was that you know in a specific knockout model in mice um this you know when we traditionally think about amyloid plaque accumulating we think about it accumulating outside the neuron and it's sort of like this whole bunch of protein that's kind of just sticking together and eventually that is injuring the neurons around us being secreted it's accumulating you know aggregating and then it's it it's causing damage that way well they show with some some really nice techniques is that what's actually happening um at least in this model is that amyloid is accumulating inside the neuron it is um aggregation uh inside failing lysosomes which is supposed to process proteins and they aggregate within the neuron which then Rises right the the cell dies and disappears and you leave a plaque in its place”