The brain's architecture and energy systems are relevant to Alzheimer's disease, with APOE variants, EPA, and DHA playing roles in cardiovascular disease and Alzheimer's risk reduction for APOE4 carriers.

“we really explain the architecture of the brain the energy systems of the brain and what goes wrong what are the various things that go wrong because it's not one thing as a person develops alzheimer's disease and then we get into what apoe is and then why we might have these three different variants or isoforms of it e2 e3 and e4 and what turns out to be different depending on which of those you have the obvious thing of course is your risk for alzheimer's disease but why we have a little side tangent that goes into sort of the role of epa in cardiovascular disease with or without dha and then kind of bring it back to this discussion around the role of dha in alzheimer's disease and also what some of the specific things that we understand to date with respect to patients that have e4 and what they can do to reduce risk”