Peter Attia· MD
so in other words he seems like a really ideal candidate if he's willing to switch more of his fat calories to monounsaturated and polyunsaturated or even just reduce fat altogether and he's willing to take the dietary steps to reduce total calories uh and maybe even carbohydrates specifically um uh to to kind of bring down um his his triglyceride so without getting into how he's going to do that can you explain why lowering triglycerides and lowering saturated fat intake those two things could bring this guy from 100 down to 60 sure the saturated fat is uh a little easier to explain we have plenty of studies that Show Excess saturated fat uh those genes that are regulating lip or those nuclear transcription factors that are regulating lipid balance in the liver and the liver is the master controller of lipid homeostasis in the body It Works hand inand with the intestine but the liver is sort of the brains of the operation so uh in many many people exposure to saturated fat the nuclear transcription factors realize oh my God fatty liver or uh fatty acid toxicity is going to occur to this liver we have to uh take our defensive mechanisms on that so what they first thing they do is say my God we don't want more lipids being pulled into the liver by these LDL receptors so the nuclear transcription factors go into your DNA and say stop making these LDL receptors stop sending out the signal that will be translated into an LDL receptor so of course if you eat saturated fat and your liver stops expressing LDL receptors your apob is going to go through the roof