Guidelines use HDL cholesterol to determine the lipid component of risk, and attempts to raise HDL cholesterol have not resulted in cardiovascular benefit.

“so all guidelines even though they might do your baseline risk using an april b metric like total or ldl cholesterol they'll use hdl cholesterol as trying to figure out the lipid component to your wrist they use smoking and blood pressure and other things peter talked about also when they get to goals of therapy though only because we have multiple trials now where for decades people have been trying this that and everything to raise hdl cholesterol because if high is better than low raising it has to be fantastic and not a single trial has ever panned out that what you do to hdl cholesterol results in cardiovascular benefit”