Peter Attia· MD
our research recent research suggests that apoe4 but not apoe3 might be able to slip slip through all of those tight junctions no not through the tight junctions the affinity of apoe4 to the lrp1 is quite higher than apoe3 and apoe2 and lrp1 is expressed at the blood-brain barrier so it could hack the system and get through endothelial lrp1 into the brain