Women may have a lower cumulative exposure to high LDL levels during their childbearing years, contributing to a later onset of ASCVD compared to men.

“at this point in a woman's life she still enjoys this for all intents and purposes decade advantage over men in terms of ascvd risk so a 40 year old woman who is still ovulating is at a cardiovascular standpoint as a 30 year old man is that directionally what we would say prior to menopause yeah I mean on average and again people are not averages you know people are individuals but on average there is a about 10-year offset of ascvd in women involving it later than men and this may be because we'll talk about when we get to menopause you know with the loss of estradiol after menopause LDL levels rise after menopause and so that women may have higher ldls a little bit later in life”