Peter Attia· MD
Wilhelm, LDL is a necessary, but not sufficient risk fact, meaning LDL alone is not going to cause atherosclerosis (need endothelial dysfunction and inflammation, also), but don't misunderstand that LDL *is* causal.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Wilhelm, LDL is a necessary, but not sufficient risk fact, meaning LDL alone is not going to cause atherosclerosis (need endothelial dysfunction and inflammation, also), but don't misunderstand that LDL *is* causal.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I absolutely believe that the lower the LDL the lower the risk of cardiovascular disease all other things equal Why because LDL is necessary but not sufficient for atherosclerosis and I say that full stop