Individuals with familial hypercholesterolemia are often medicated for high ApoB levels, typically starting in their teenage years, indicating that aggressive lipid lowering is not a novel concept.

“although it's clearly something we do in the subset of patients who have significant genetic abnormalities such as the cluster of genetic abnormalities that coalesce around a condition called familial hypercholesterolemia we certainly do medicate those patients usually as teenagers”