Peter Attia· MD
in order to see that flux you need to block the degradation of lc3 too and the lysosome with baffle oh my son or hydroxychloroquine
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
in order to see that flux you need to block the degradation of lc3 too and the lysosome with baffle oh my son or hydroxychloroquine
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you could take PBMCs and do a Western blot for lc3 and lc3 gets processed from lc3 one to two and the two form is the one that's attached to the auto phagosome membrane so you could do a Western blot though PBMC is to measure the conversion of one to two but then to ends up in the lysosome gets degraded so the typical measurement of what auto fat check flux involves measuring the rate at which the lc3 one gets converted to lc3 2 and then the rate at which lc3 2 ends up being degraded in the and in order to see that flux you need to block the degradation of lc3 too and the lysosome with baffle oh my son or hydroxychloroquine
you can pull out blood cells and you can look at, you know, white cells and see, you know, whether autophagy pathways are induced or not. You can take muscle biopsies.