The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you have elevated homocysteine uh so a level above 13 and you reduce that by giving somebody B vitamin so particularly B12 folate B2 and they have adequate omega-3 status see there seems to be an interaction then you can significantly slow um brain atrophy and slow cognitive decline
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in people with Alzheimer's risk and precision medicine where if someone has an elevated homocysteine but they're treated with B vitamins they can slow overall brain atrophy and improve memory however that will only work if you have optimized omega-3 fatty acids
what they showed was that the the rate of brain atrophy was uh only slowed in those who had in the highest tertile of Omega-3 status there was a study in the Netherlands the bee proof study uh where they they also showed that um the benefit was greatest in those who had the highest levels of DHA
but then sort of more broadly and where I think you know the majority of the action is and sort of excluding cardiovascular is the importance of the methylation cycle in creating functional neuronal membranes and the reason why I think uh this is because of evidence of how home assisting level or B vitamin supplementation interacts with omega-3 status