Peter Attia· MD
the first is that it is a weak am p kinase activator and for those of you that have you know shown an interest in what metformin does that's sort of the the that's probably the secret sauce of metformin is its AMPK activation so berberine when taken at you know sort of recommended OTC doses which I remember the doses anymore I think it's like a it might be actually a comparable dose to metformin it might be like either 500 twice a day or a thousand twice a day does have some of that weak ampk activation and what that the net effect of that is it decreases hepatic glucose output so it's up regulating ampk is telling the liver hey you can make less glucose so send less glucose out of the body