Proteomics studies show dramatic changes in plasma proteome throughout life, suggesting significant alterations in gene expression with age.

“he has shown for example proteome in plasma changes throughout life y pretty dramatic matter which is really completely mindboggling for me to see that you can be so different as you age uh in terms of your whole blood prote why I mean wouldn't you if if the epiggenome is changing then gene expression is changing if gene expression is changing no yeah yeah yeah it's okay but we and we haven't you know so they've used this to that it would change to such a degree Tony has a beautiful slide which shows you know all of the proteium in the blood and how the colors changed across and do you think that most of those changes are post-transational no Most of them are probably expression level. It's expression. Yeah, it's expression. Okay.”