Alkaline phosphatase can be fractionated into heat-labile (bone) and heat-stable (liver) components to determine the source of elevation.

“if alkaline phosphatase is elevated we will fraction ate outcome in phosphatase into a heat labile or heat stable and the acronym we had from medical school was that bone burns meaning that if the alkaline phosphatase is elevated because of something happening in the bones a probably a pathogenic process in the bones it will be degraded by heat and that if the alkaline phosphatase is coming from the liver it will not be degraded by heat so you can fractionate the al the alkaline phosphatase”