Paul Saladino· MD
And and if it's high, I mean, it's it's very clear that um that that something's going on that needs to be changed in the human body.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And and if it's high, I mean, it's it's very clear that um that that something's going on that needs to be changed in the human body.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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And that's a really interesting thing for me because it's connected like that and fasting insulin I think are the the most interesting blood work analyses that I've learned about since finishing residency and, you know, doing what I do now as a physician.
Um that that's actually really well studied and there's actually really good data. I can send you some looking at like longevity Paul. I wasn't aware of that, but that you're right. I mean, that would be amazing to get a good validated marker of stress, absolutely. Yeah, there's good data on morbidity, well at least mortality, and longevity with cortisol to DHEA-S.
a higher cortisol to dheas ratio was related to an increased risk of death by other causes in the age adjusted model the hazard ratio was 3.11 that's a pretty significant that's like three times higher risk with an increased higher cortisol to dheas ratio
basically the authors say that this is one of the best ratios for longevity and predicting low rates of cause specific mortality and all cause mortality
there's there's one lab ratio. We're getting a little granular with labs, but you know, you've got DHEA sulfate to cortisol ratio, and that ratio is very predictive of longevity.