Using both DNA sequence and blood phenylalanine levels improves the accuracy of PKU screening.

“so you're right that in this case we use two different data streams to come in um the other reason why the phenotype alone is imperfect is you can imagine depending on what you've eaten your phenyalanine levels fluctuate during the course of the day and so we do it as a crosssectional one time and you might happen to get a baby at just the wrong time or just a you know sort of higher level and so being able to have both of those data streams come in allow us to be even better in terms of the accuracy”