LDL particle number is determined by triglycerides, cholesterol synthesis, cholesterol reabsorption, and LDL receptor profile.

“when you look at LDL P just to contrast it and remind triglycerides when you look at LDL P you go back to four things that determine the number of those particles three of them have to do with how much you carry one of them has to do with how much you clear so three about the cargo one about the port how many triglycerides do you have how much cholesterol do you synthesize how much esterified cholesterol or non-esterified cholesterol rather do you reabsorb in the after it passes through the biliary system in the NRO site and then what's your LDL receptor profile look like primarily in the liver but also in the gut”