A polymorphism in the HFE gene (rs1800562, CE282Y) predisposes individuals to primary hemochromatosis, causing avid iron absorption.

“there is a small number of people who have a polymorphism in a gene called the HFE gene or the human homeostatic iron regulator protein gene HFE and these people are predisposed to hemochromatosis there are multiple types of hemochromatosis but what we're talking about now is primary quemic romo ptosis that is hemochromatosis which is iron overload because of a polymorphism in the HFE gene which causes us to absorb iron avidly and not really have the ability to stop absorbing it when we're exposed to it”