The ketogenic diet's effectiveness in managing epilepsy is largely attributed to calorie restriction and maintaining low blood sugar levels.

“we published this big paper on calorie restriction and key to it was well that the ketogenic diet was working largely through calorie restriction and maintaining low blood sugar levels was the key to maintaining control of seizures”

“you know what's what's working she said you know a lot of times these drugs work through calorie restriction so I said well why don't we put a control group we all decided let's put a control group for body weights and then we just won one was the guys with the drug and losing weight the other guys would just take the food away from them so the body weights would be absolutely identical so they were pair fat pad wasn't pair fat one one group was eating ad libitum and they were losing body weight and the other group oh I see you took a guess we had to restrict the calories to match to match the body weight were their pair we did yesterday waited yes Ida waited and then we evaluated this and the tumors were exactly the same size so it had nothing to do with the drug even though the drug was working on the target and molecule it wasn't the targeted molecule that was was responsible for this so that's when we also decided with the epilepsy overlapping does the categorize the ketogenic diet work through calorie restriction because many of these children that get ketogenic diets they have a very restricted calories and you have to you have to give very small you can't let kids eat massive amounts of fat because invariably John Freeman told me it doesn't think the diet doesn't work if they just fight one out of two or three hundred kids just loves to eat all this fat and they then the seizures don't go away”