The K-Ras mutation activates the MAPK pathway, leading to perpetual cell proliferation.

“k RAF's is a GTP binding protein that is responsible for activating what's called the map kinase pathway and this pathway is very key and driving cell proliferation and so cancers have a mutation and rass or mutations and rafts that leave it in the GTP bound or on States so there's perpetual growth signaling through the map kinase pathway which of course is the hallmark of cancer which is it's unresponsive to cell signaling and when you are fixed in the on position you can't turn off and basically that is cancer”