oncogenes they screw up all sorts of things one of them is the the stress response and you know cancer cells can't respond just read their prime to die I mean it's I spent a long time meena studying cancer cell metabolism apoptosis with Doug green and Joseph opperman at st. Jude Children's Research Hospital and and that's kind of one of the primary ways that a lot of these chemo therapeutic drugs if they can get to the tumor site work is that because it's a stress cancer cells can't handle it you know they die